Glioblastoma

Authors

Steven De Vleeschouwer, MD, PhD
Department of Neurosurgery, University Hospitals Leuven, Belgium

Synopsis

Glioblastoma is the commonest and the most lethal brain tumor. In this book 71 experts from around the globe come together to give a timely, unique and exhaustive compilation of preclinical and clinical knowledge and concepts of glioblastoma under three sections: understanding glioblastoma in the lab; managing glioblastoma in the clinic; and upcoming cutting-edge innovations. In section one, seven chapters provide a comprehensive overview of the molecular genetics, biological hallmarks and current state-of-the-art preclinical animal models in glioblastoma research. In section two, eight chapters deal with the many diagnostic, therapeutic and prognostic management challenges physicians are facing every day. In section three, six chapters try to capture innovative approaches and techniques that might have the potential to gain impact in the field in the coming years. Number of Chapters: 21; Contributors: 71; Figures: 64; Tables: 27; Pages: 432.

Electronic version is freely available. Hardcover copies are available at books@codonpublications.com

Chapters

  • Front Matter
    Pages..... i-vii
  • Foreword
    Prof. Dr. med. W. Stummer.....Page ix
  • Preface
    Steven De Vleeschouwer.....Pages xi-xii
  • Contributors
    Pages.....xiii-xx
  • Chapter 1: Glioblastoma Genomics: A Very Complicated Story
    Melanie Y. Lombardi, Mahfoud Assem.....Pages 3-25
  • Chapter 2: Molecular Genetics of Secondary Glioblastoma
    Alireza Mansouri, Jason Karamchandani, Sunit Das.....Pages 27-42
  • Chapter 3: Epigenetic Mechanisms of Glioblastoma
    Peiyao Li, Minghua Wu.....Pages 43-58
  • Chapter 4: Cancer Stem-Like Cells in Glioblastoma
    Mathilde Cheray, Gaëlle Bégaud, Elise Deluche, Alexandre Nivet, Serge Battu, Fabrice Lalloué, Mireille Verdier, Barbara Bessette.....Pages 59-71
  • Chapter 5: Molecular Mechanisms of Glioma Cell Motility
    Angela Armento, Jakob Ehlers, Sonja Schötterl, Ulrike Naumann.....Pages 73-93
  • Chapter 6: Noncoding RNAs in Glioblastoma
    Ying Zhang, Nichola Cruickshanks, Mary Pahuski, Fang Yuan, Anindya Dutta, David Schiff, Benjamin Purow, Roger Abounader.....Pages 95-130
  • Chapter 7: Mouse Models of Glioblastoma
    Noriyuki Kijima, Yonehiro Kanemura.....Pages 131-139
  • Chapter 8: Epidemiology and Outcome of Glioblastoma
    Ahmad Faleh Tamimi, Malik Juweid.....Pages 143-153
  • Chapter 9: PET Imaging in Glioblastoma: Use in Clinical Practice
    Antoine Verger, Karl-Josef Langen.....Pages 155-174
  • Chapter 10: PET for Therapy Response Assessment in Glioblastoma
    Julie Bolcaen, Marjan Acou, Benedicte Descamps, Ken Kersemans, Karel Deblaere, Christian Vanhove, Ingeborg Goethals.....Pages 175-195
  • Chapter 11: Current Standards of Care in Glioblastoma Therapy
    Catarina Fernandes, Andreia Costa, Lígia Osório, Rita Costa Lago, Paulo Linhares, Bruno Carvalho, Cláudia Caeiro.....Pages 197-241
  • Chapter 12: Surgical Management of Glioblastoma
    Salvador Manrique-Guzmán, Tenoch Herrada-Pineda, Francisco Revilla-Pacheco.....Pages 243-261
  • Chapter 13: Cortical Mapping in the Resection of Malignant Cerebral Gliomas
    Jehad Zakaria, Vikram C. Prabhu.....Pages 263-280
  • Chapter 14: Recurring Glioblastoma: A Case for Reoperation?
    Joost Dejaegher, Steven De Vleeschouwer.....Pages 281-296
  • Chapter 15: Pediatric Glioblastoma
    Kuntal Kanti Das, Raj Kumar.....Pages 297-312
  • Chapter 16: Glioblastoma: To Target the Tumor Cell or the Microenvironment?
    Steven De Vleeschouwer, Gabriele Bergers.....Pages 315-340
  • Chapter 17: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part I: Targeted Cytotoxic Therapy
    Waldemar Debinski, Waldemar Priebe, Stephen Tatter.....Pages 341-358
  • Chapter 18: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part II: Arborizing Catheter for Convection-Enhanced Delivery in Tissue Phantoms
    Egleide Y. Elenes, Christopher Rylander.....Pages 359-372
  • Chapter 19: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part III: Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Eradication of Glioblastoma
    Melvin F. Lorenzo, Christopher B. Arena, Rafael V. Davalos.....Pages 373-393
  • Chapter 20: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part IV: Image-Guided, Remote- Controlled Opening of the Blood–Brain Barrier for Systemic Brain Tumor Therapy
    Anirudh Sattiraju, Yao Sun, Kiran Kumar Solingapuram Sai, King C.P. Li, Akiva Mintz.....Pages 395-404
  • Chapter 21: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches
    John Rossmeisl.....Pages 405-425
  • Index
    Pages.....427-432

Author Biography

Steven De Vleeschouwer, MD, PhD, Department of Neurosurgery, University Hospitals Leuven, Belgium


Professor Steven De Vleeschouwer, MD, PhD is staff neurosurgeon at the University Hospitals, Leuven, Belgium, where he is responsible for the clinical care program of patients with intracranial tumors. He holds a part-time professorship at the Neurosciences department at KU Leuven, Belgium and is head of the Laboratory of Experimental Neurosurgery and Neuroanatomy. He is the current Chair of the Belgian Association of Neuro-oncology (BANO), extended board member of the Belgian Society for Neurosurgery (BSN) and an active member of the European Association of Neurosurgical Societies (EANS), the European Association of Neuro-oncology (EANO) and the Society of Neuro-oncology (SNO). He is co-founder of the Belgian Brain Tumor Support (BBTS). He actively trains residents in neurosurgery and supervises many PhD projects. Professor De Vleeschouwer is peer-reviewer for more than 25 scientific journals and serves on the editorial board of 4 biomedical journals. His main research interests comprise both clinical and experimental neuro-oncology and include functional and morphological demarcation tools in brain tumor surgery, basic and applied brain tumor immunology and strategies to modify the brain tumor micro-environment.

Cover for Glioblastoma
Published
September 20, 2017

Details about the available publication format: Front Matter

Front Matter
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017

Details about the available publication format: Foreword

Foreword
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.fr

Details about the available publication format: Preface

Preface
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.pr

Details about the available publication format: Contributors

Contributors
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.cont

Details about the available publication format: Chapter 1: Glioblastoma Genomics: A Very Complicated Story

Chapter 1: Glioblastoma Genomics: A Very Complicated Story
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch1

Details about the available publication format: Chapter 2: Molecular Genetics of Secondary Glioblastoma

Chapter 2: Molecular Genetics of Secondary Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch2

Details about the available publication format: Chapter 3: Epigenetic Mechanisms of Glioblastoma

Chapter 3: Epigenetic Mechanisms of Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch3

Details about the available publication format: Chapter 4: Cancer Stem-Like Cells in Glioblastoma

Chapter 4: Cancer Stem-Like Cells in Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch4

Details about the available publication format: Chapter 5: Molecular Mechanisms of Glioma Cell Motility

Chapter 5: Molecular Mechanisms of Glioma Cell Motility
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch5

Details about the available publication format: Chapter 6: Noncoding RNAs in Glioblastoma

Chapter 6: Noncoding RNAs in Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch6

Details about the available publication format: Chapter 7: Mouse Models of Glioblastoma

Chapter 7: Mouse Models of Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch7

Details about the available publication format: Chapter 8: Epidemiology and Outcome of Glioblastoma

Chapter 8: Epidemiology and Outcome of Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch8

Details about the available publication format: Chapter 9: PET Imaging in Glioblastoma: Use in Clinical Practice

Chapter 9: PET Imaging in Glioblastoma: Use in Clinical Practice
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch9

Details about the available publication format: Chapter 10: PET for Therapy Response Assessment in Glioblastoma

Chapter 10: PET for Therapy Response Assessment in Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch10

Details about the available publication format: Chapter 11: Current Standards of Care in Glioblastoma Therapy

Chapter 11: Current Standards of Care in Glioblastoma Therapy
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch11

Details about the available publication format: Chapter 12: Surgical Management of Glioblastoma

Chapter 12: Surgical Management of Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch12

Details about the available publication format: Chapter 13: Cortical Mapping in the Resection of Malignant Cerebral Gliomas

Chapter 13: Cortical Mapping in the Resection of Malignant Cerebral Gliomas
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch13

Details about the available publication format: Chapter 14: Recurring Glioblastoma: A Case for Reoperation?

Chapter 14: Recurring Glioblastoma: A Case for Reoperation?
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch14

Details about the available publication format: Chapter 15: Pediatric Glioblastoma

Chapter 15: Pediatric Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch15

Details about the available publication format: Chapter 16: Glioblastoma: To Target the Tumor Cell or the Microenvironment?

Chapter 16: Glioblastoma: To Target the Tumor Cell or the Microenvironment?
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch16

Details about the available publication format: Chapter 17: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part I: Targeted Cytotoxic Therapy

Chapter 17: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part I: Targeted Cytotoxic Therapy
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch17

Details about the available publication format: Chapter 18: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part II: Arborizing Catheter for Convection-Enhanced Delivery in Tissue Phantoms

Chapter 18: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part II: Arborizing Catheter for Convection-Enhanced Delivery in Tissue Phantoms
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch18

Details about the available publication format: Chapter 19: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part III: Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Eradication of Glioblastoma

Chapter 19: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part III: Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Eradication of Glioblastoma
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch19

Details about the available publication format: Chapter 20: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part IV: Image-Guided, Remote- Controlled Opening of the Blood–Brain Barrier for Systemic Brain Tumor Therapy

Chapter 20: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part IV: Image-Guided, Remote- Controlled Opening of the Blood–Brain Barrier for Systemic Brain Tumor Therapy
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch20

Details about the available publication format: Chapter 21: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches

Chapter 21: Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part V: Clinically Relevant Model for Testing New Therapeutic Approaches
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ch21

Details about the available publication format: Index

Index
ISBN-13 (15)
978-0-9944381-2-6
doi
10.15586/codon.glioblastoma.2017.ind