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Wilms Tumor: ISBN 978-0-9944381-1-9

Publication Info

Added 2016-12-03

Front Matter

ISBN-13: 978-0-9944381-1-9

Foreword

ISBN-13: 978-0-9944381-1-9

Preface

ISBN-13: 978-0-9944381-1-9

Contributors

ISBN-13: 978-0-9944381-1-9

Chapter 1

ISBN-13: 978-0-9944381-1-9

Chapter 2

ISBN-13: 978-0-9944381-1-9

Chapter 3

ISBN-13: 978-0-9944381-1-9

Chapter 4

ISBN-13: 978-0-9944381-1-9

Chapter 5

ISBN-13: 978-0-9944381-1-9

Chapter 6

ISBN-13: 978-0-9944381-1-9

Chapter 7

ISBN-13: 978-0-9944381-1-9

Chapter 8

ISBN-13: 978-0-9944381-1-9

Chapter 9

ISBN-13: 978-0-9944381-1-9

Chapter 10

ISBN-13: 978-0-9944381-1-9

Chapter 11

ISBN-13: 978-0-9944381-1-9

Chapter 12

ISBN-13: 978-0-9944381-1-9

Chapter 13

ISBN-13: 978-0-9944381-1-9

Chapter 14

ISBN-13: 978-0-9944381-1-9

Chapter 15

ISBN-13: 978-0-9944381-1-9

Chapter 16

ISBN-13: 978-0-9944381-1-9

Index

ISBN-13: 978-0-9944381-1-9

Book

ISBN-13: 978-0-9944381-1-9

Wilms Tumor: ISBN 978-0-9944381-1-9

Marry M. van den Heuvel-Eibrink, MD, PhD

Wilms tumor is a rare kidney cancer that is usually diagnosed in children under the age of six. Wilms tumor is mostly the result of aberrations in WT1 gene, located on chromosome 11p13. In addition to being a risk factor for Wilms tumor, WT1 aberrations cause extra renal complications and other malignancies. This book brings together the basic and clinical aspects of Wilms tumor and WT1 research under three sections. Section I provides a comprehensive guide to the epidemiology, diagnostics, management, and treatment of Wilms tumor. Section II covers the biological aspects of Wilms tumor and WT1. Section III focuses on the role of WT1 in cardiac development, prostate cancer, glioblastoma and minimal residual disease.

Contributors: 64

Chapters: 16

Figures: 50

Tables: 20

Pages: 294

About the Volume editor: Marry M. van den Heuvel-Eibrink, MD, PhD

Professor Marry M. van den Heuvel-Eibrink, MD, PhD, is a senior consultant in pediatric oncology and hematology at the Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, where she is responsible for the now established centralized care and translational research program for all children with renal tumors in the Netherlands. She is the current Chair of the European Working Group on Myelodysplastic Syndromes (EWOG-MDS) foundation, and the Dutch Childhood Oncology Group (DCOG) renal tumor committee.  She is the co-chair of the International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG), steering committee member of the DCOG late effects consortium, and an active member of IBFM-AML study group. From 1997-2014 she was a senior consultant at the Erasmus MC-Sophia Children’s Hospital, Rotterdam. During this period, she was the Working Group leader of the Erasmus MC Postgraduate Molecular Medicine School, which is recognized by the Dutch Royal Academy of Science and Arts. Her major research interest is translational research in pediatric cancer, with a special focus on renal tumors, and the (genetic) variation of early and late childhood cancers. Professor van den Heuvel-Eibrink has published over 260 international peer reviewed manuscripts and is the supervisor of over 25 finalized and ongoing PhD projects. 

Front Matter
Pages i-vii

Foreword
Bengt Sandstedt.....Pages ix-xi

Preface
Marry M. van den Heuvel-Eibrink.....Pages xiii-xv

Contributors
Pages xvii-xxiii

Chapter 1: Wilms’ Tumour – Histology and Differential Diagnosis
Sergey D. Popov, Neil J. Sebire, Gordan M. Vujanic.....Pages 3-21

Chapter 2: The Clinical Relevance of Age at Presentation in Nephroblastoma
Saskia L. Gooskens, Heidi Segers, Kathy Pritchard-Jones, Norbert Graf, Jeffrey S. Dome, Marry M. van den Heuvel-Eibrink.....Pages 23-30

Chapter 3: Histopathological and Molecular Characteristics of Wilms Tumor
Gulden Diniz.....Pages 31-41

Chapter 4: Wilms Tumor and Its Management in a Surgical Aspect
Basak Erginel.....Pages 43-59

Chapter 5: Management of Bilateral Wilms Tumours
Alastair J. W. Millar, Sharon Cox, Alan Davidson.....Pages 61-76

Chapter 6: Extrarenal Wilms’ Tumor: Challenges in Diagnosis, Embryology, Treatment and Prognosis
Reza Shojaeian, Mehran Hiradfar, Parisa Saeedi Sharifabad, Nona Zabolinejad.....Pages 77-93

Chapter 7: Neoadjuvant Transcatheter Arterial Chemoembolization and Systemic Chemotherapy for the Treatment of Wilms Tumor
Min-Ju Li, Da-Xing Tang, Shan Xu, Yong Huang, De-Hua Wu, Jin-Hu Wang, Can Lai, Hong-Feng Tang, Qiang Shu.....Pages 95-112

Chapter 8: Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer
Shigetaka Shimodaira, Koichi Hirabayashi, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Tomonobu Koizumi.....Pages 113-130

Chapter 9: Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?
Joanna Stefanowicz, Mateusz Kosiak, Wojciech Kosiak, Beata S. Lipska-Ziętkiewicz.....Pages 131-145

Chapter 10: Gene Expression in Wilms Tumor: Disturbance of the Wnt Signaling Pathway and MicroRNA Biogenesis
Dirce Maria Carraro, Rodrigo F. Ramalho, Mariana Maschietto.....Pages 149-162

Chapter 11: Transcriptional Regulation of the Human Thromboxane A2 Receptor Gene by Wilms’ Tumour (WT)1
B. Therese Kinsella.....Pages 163-187

Chapter 12: The Inflammatory Microenvironment in Wilms Tumors
Paramahamsa Maturu.....Pages 189-207

Chapter 13: WT1 in Cardiac Development and Disease
Sjoerd N. Duim, Marie-José Goumans, Boudewijn P. T. Kruithof.....Pages 211-233

Chapter 14: Functional Role of WT1 in Prostate Cancer
Gail C. Fraizer, Kurtis Eisermann, Sony Pandey, Adina Brett-Morris, Anton Bazarov, Sarah Nock, Nirmala Ghimirey, Steven J. Kuerbitz.....Pages 235-259

Chapter 15: Functional Roles of Wilms’ Tumor 1 (WT1) in Malignant Brain Tumors
Noriyuki Kijima, Naoya Hashimoto, Yasuyoshi Chiba, Yasunori Fujimoto, Haruo Sugiyama, Toshiki Yoshimine.....Pages 261-272

Chapter 16: Wilms’ Tumor Gene (WT1) Expression and Minimal Residual Disease in Acute Myeloid Leukemia
Giovanni Rossi, Maria Marta Minervini, Angelo Michele Carella, Lorella Melillo, Nicola Cascavilla.....Pages 273-285

Index
Pages 287-293

Book
The Whole Book

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  • Front Matter…..Pages i-vii
  • Foreword…..Pages ix-xi
  • Preface….. Pages xiii-xv
  • Contributors…..Pages xvii-xxiii
  • Chapter 1: Wilms’ Tumour – Histology and Differential Diagnosis.....Pages 3-21
  • Chapter 2: The Clinical Relevance of Age at Presentation in Nephroblastoma.....Pages 23-30
  • Chapter 3: Histopathological and Molecular Characteristics of Wilms Tumor.....Pages 31-41
  • Chapter 4: Wilms Tumor and Its Management in a Surgical Aspect.....Pages 43-59
  • Chapter 5: Management of Bilateral Wilms Tumours.....Pages 61-76
  • Chapter 6: Extrarenal Wilms’ Tumor: Challenges in Diagnosis, Embryology, Treatment and Prognosis.....Pages 77-93
  • Chapter 7: Neoadjuvant Transcatheter Arterial Chemoembolization and Systemic Chemotherapy for the Treatment of Wilms Tumor.....Pages 95-112
  • Chapter 8: Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer.....Pages 113-130
  • Chapter 9: Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today? .....Pages 131-145
  • Chapter 10: Gene Expression in Wilms Tumor: Disturbance of the Wnt Signaling Pathway and MicroRNA Biogenesis.....Pages 149-162
  • Chapter 11: Transcriptional Regulation of the Human Thromboxane A2 Receptor Gene by Wilms’ Tumour (WT)1.....Pages 163-187
  • Chapter 12: The Inflammatory Microenvironment in Wilms Tumors.....Pages 189-207
  • Chapter 13: WT1 in Cardiac Development and Disease.....Pages 211-233
  • Chapter 14: Functional Role of WT1 in Prostate Cancer.....Pages 235-259
  • Chapter 15: Functional Roles of Wilms’ Tumor 1 (WT1) in Malignant Brain Tumors.....Pages 261-272
  • Chapter 16: Wilms’ Tumor Gene (WT1) Expression and Minimal Residual Disease in Acute Myeloid Leukemia.....Pages 273-285
  • Index…..Pages 287-293
  • Book
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