Wilms Tumor

Authors

Marry M. van den Heuvel-Eibrink, MD, PhD
Princess Maxima Center for Pediatric Oncology/Hematology, Lundlaan 6, 3584 EA Utrecht, The Netherlands

Synopsis

Wilms tumor is a rare kidney cancer that is usually diagnosed in children under the age of six. Wilms tumor is mostly the result of aberrations in WT1 gene, located on chromosome 11p13. In addition to being a risk factor for Wilms tumor, WT1 aberrations cause extra renal complications and other malignancies. This book brings together the basic and clinical aspects of Wilms tumor and WT1 research under three sections. Section I provides a comprehensive guide to the epidemiology, diagnostics, management, and treatment of Wilms tumor. Section II covers the biological aspects of Wilms tumor and WT1. Section III focuses on the role of WT1 in cardiac development, prostate cancer, glioblastoma and minimal residual disease. Number of Chapters: 16; Contributors: 64; Figures: 50; Tables: 20; Pages: 294.

Electronic version is freely available. Hardcover copies are available at books@codonpublications.com

Chapters

  • Front Matter
    Pages i-vii
  • Foreword
    Bengt Sandstedt.....Pages ix-xi
  • Preface
    Marry M. van den Heuvel-Eibrink.....Pages xiii-xv
  • Contributors
    Pages xvii-xxiii
  • Chapter 1: Wilms’ Tumour – Histology and Differential Diagnosis
    Sergey D. Popov, Neil J. Sebire, Gordan M. Vujanic.....Pages 3-21
  • Chapter 2: The Clinical Relevance of Age at Presentation in Nephroblastoma
    Saskia L. Gooskens, Heidi Segers, Kathy Pritchard-Jones, Norbert Graf, Jeffrey S. Dome, Marry M. van den Heuvel-Eibrink.....Pages 23-30
  • Chapter 3: Histopathological and Molecular Characteristics of Wilms Tumor
    Gulden Diniz.....Pages 31-41
  • Chapter 4: Wilms Tumor and Its Management in a Surgical Aspect
    Basak Erginel.....Pages 43-59
  • Chapter 5: Management of Bilateral Wilms Tumours
    Alastair J. W. Millar, Sharon Cox, Alan Davidson.....Pages 61-76
  • Chapter 6: Extrarenal Wilms’ Tumor: Challenges in Diagnosis, Embryology, Treatment and Prognosis
    Reza Shojaeian, Mehran Hiradfar, Parisa Saeedi Sharifabad, Nona Zabolinejad.....Pages 77-93
  • Chapter 7: Neoadjuvant Transcatheter Arterial Chemoembolization and Systemic Chemotherapy for the Treatment of Wilms Tumor
    Min-Ju Li, Da-Xing Tang, Shan Xu, Yong Huang, De-Hua Wu, Jin-Hu Wang, Can Lai, Hong-Feng Tang, Qiang Shu.....Pages 95-112
  • Chapter 8: Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer
    Shigetaka Shimodaira, Koichi Hirabayashi, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Tomonobu Koizumi.....Pages 113-130
  • Chapter 9: Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?
    Joanna Stefanowicz, Mateusz Kosiak, Wojciech Kosiak, Beata S. Lipska-Ziętkiewicz.....Pages 131-145
  • Chapter 10: Gene Expression in Wilms Tumor: Disturbance of the Wnt Signaling Pathway and MicroRNA Biogenesis
    Dirce Maria Carraro, Rodrigo F. Ramalho, Mariana Maschietto.....Pages 149-162
  • Chapter 11: Transcriptional Regulation of the Human Thromboxane A2 Receptor Gene by Wilms’ Tumour (WT)1
    B. Therese Kinsella.....Pages 163-187
  • Chapter 12: The Inflammatory Microenvironment in Wilms Tumors
    Paramahamsa Maturu.....Pages 189-207
  • Chapter 13: WT1 in Cardiac Development and Disease
    Sjoerd N. Duim, Marie-José Goumans, Boudewijn P. T. Kruithof.....Pages 211-233
  • Chapter 14: Functional Role of WT1 in Prostate Cancer
    Gail C. Fraizer, Kurtis Eisermann, Sony Pandey, Adina Brett-Morris, Anton Bazarov, Sarah Nock, Nirmala Ghimirey, Steven J. Kuerbitz.....Pages 235-259
  • Chapter 15: Functional Roles of Wilms’ Tumor 1 (WT1) in Malignant Brain Tumors
    Noriyuki Kijima, Naoya Hashimoto, Yasuyoshi Chiba, Yasunori Fujimoto, Haruo Sugiyama, Toshiki Yoshimine.....Pages 261-272
  • Chapter 16: Wilms’ Tumor Gene (WT1) Expression and Minimal Residual Disease in Acute Myeloid Leukemia
    Giovanni Rossi, Maria Marta Minervini, Angelo Michele Carella, Lorella Melillo, Nicola Cascavilla.....Pages 273-285
  • Index
    Pages 287-293
  • Book
    The Whole Book

Biography

Marry M. van den Heuvel-Eibrink, MD, PhD, Princess Maxima Center for Pediatric Oncology/Hematology, Lundlaan 6, 3584 EA Utrecht, The Netherlands


Professor Marry M. van den Heuvel-Eibrink, MD, PhD, is a senior consultant in pediatric oncology and hematology at the Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, where she is responsible for the now established centralized care and translational research program for all children with renal tumors in the Netherlands. She is the current Chair of the European Working Group on Myelodysplastic Syndromes (EWOG-MDS) foundation, and the Dutch Childhood Oncology Group (DCOG) renal tumor committee.  She is the co-chair of the International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG), steering committee member of the DCOG late effects consortium, and an active member of IBFM-AML study group. From 1997-2014 she was a senior consultant at the Erasmus MC-Sophia Children’s Hospital, Rotterdam. During this period, she was the Working Group leader of the Erasmus MC Postgraduate Molecular Medicine School, which is recognized by the Dutch Royal Academy of Science and Arts. Her major research interest is translational research in pediatric cancer, with a special focus on renal tumors, and the (genetic) variation of early and late childhood cancers. Professor van den Heuvel-Eibrink has published over 260 international peer reviewed manuscripts and is the supervisor of over 25 finalized and ongoing PhD projects. 

Cover for Wilms Tumor

Details about the available publication format: Front Matter

Front Matter
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016

Details about the available publication format: Foreword

Foreword
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.fr

Details about the available publication format: Preface

Preface
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.pr

Details about the available publication format: Contributors

Contributors
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.cont

Details about the available publication format: Chapter 1

Chapter 1
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch1

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Chapter 2
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch2

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Chapter 3
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch3

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Chapter 4
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch4

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Chapter 5
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch5

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Chapter 6
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch6

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Chapter 7
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch7

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Chapter 8
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch8

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Chapter 9
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch9

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Chapter 10
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch10

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Chapter 11
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch11

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Chapter 12
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch12

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Chapter 13
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch13

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Chapter 14
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch14

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Chapter 15
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch15

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Chapter 16
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ch16

Details about the available publication format: Index

Index
ISBN-13 (15)
978-0-9944381-1-9
doi
10.15586/codon.wt.2016.ind

Details about the available publication format: Book

Book
ISBN-13 (15)
978-0-9944381-1-9