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Polycystic Kidney Disease: ISBN 978-0-9944381-0-2

Publication Info

Added 2016-03-21

Front Matter

ISBN-13: 978-0-9944381-0-2

Foreword

ISBN-13: 978-0-9944381-0-2

Preface

ISBN-13: 978-0-9944381-0-2

Contributors

ISBN-13: 978-0-9944381-0-2

Chapter 1

ISBN-13: 978-0-9944381-0-2

Chapter 2

ISBN-13: 978-0-9944381-0-2

Chapter 3

ISBN-13: 978-0-9944381-0-2

Chapter 4

ISBN-13: 978-0-9944381-0-2

Chapter 5

ISBN-13: 978-0-9944381-0-2

Chapter 6

ISBN-13: 978-0-9944381-0-2

Chapter 7

ISBN-13: 978-0-9944381-0-2

Chapter 8

ISBN-13: 978-0-9944381-0-2

Chapter 9

ISBN-13: 978-0-9944381-0-2

Chapter 10

ISBN-13: 978-0-9944381-0-2

Chapter 11

ISBN-13: 978-0-9944381-0-2

Chapter 12

ISBN-13: 978-0-9944381-0-2

Chapter 13

ISBN-13: 978-0-9944381-0-2

Chapter 14

ISBN-13: 978-0-9944381-0-2

Chapter 15

ISBN-13: 978-0-9944381-0-2

Chapter 16

ISBN-13: 978-0-9944381-0-2

Chapter 17

ISBN-13: 978-0-9944381-0-2

Chapter 18

ISBN-13: 978-0-9944381-0-2

Chapter 19

ISBN-13: 978-0-9944381-0-2

Chapter 20

ISBN-13: 978-0-9944381-0-2

Index

ISBN-13: 978-0-9944381-0-2

Book

ISBN-13: 978-0-9944381-0-2

Polycystic Kidney Disease: ISBN 978-0-9944381-0-2

Xiaogang Li, PhD

Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD. Section 2 covers most of the fundamental molecular and cellular mechanisms underlying PKD, and how this knowledge is contributing to the development of potential novel therapeutic agents. Finally, section 3 focuses on extra-renal or secondary complications of PKD.

Contributors: 48

Chapters: 20

Figures: 42

Tables: 12

Pages: 488

About the Volume editor: Xiaogang Li, PhD

Xiaogang Li, PhD, is the Director of the Epigenetics Core at the Kansas Polycystic Kidney Disease (PKD) Research and Translational Core Center, supported by the National Institutes of Health of the United States of America (USA). He is Associate Professor of Internal Medicine at the University of Kansas Medical Center (KUMC), USA. He also holds academic appointments at the Departments of Biochemistry and Molecular Biology, Anatomy and Cell Biology, and Cancer Biology at KUMC. His research encompasses both basic science and translational aspects of PKD. In particular, he is widely regarded as one of the world’s foremost authorities on epigenetics and renal inflammation in PKD. Furthermore, he re-evaluates the roles of apoptosis in autosomal dominant PKD, contributing to a better understanding of the mechanisms of this disease. He has published extensively in the field including publications in Nature Cell Biology, Nature Medicine, and Journal of Clinical Investigation. His studies are leading to the use of promising new therapeutic drugs in PKD treatment. 

Front Matter
Pages i-vii

Foreword
Jared J. Grantham.....Pages ix-x

Preface
Xiaogang Li.....Pages xi-xiii

Contributors
Pages xv-xx

Chapter 1: Differential Diagnosis of Autosomal Dominant Polycystic Kidney Disease
Mariana Alves, Teresa Fonseca, Edgar A. F. de Almeida.....Pages 3-19

Chapter 2: Childhood Polycystic Kidney Disease
Ameya Patil, William E. Sweeney Jr., Ellis D. Avner, Cynthia Pan.....Pages 21-60

Chapter 3: Treatment and Management of Autosomal Dominant Polycystic Kidney Disease
Imed Helal.....Pages 61-73

Chapter 4: Diagnosis and Treatment Modalities of Symptomatic Polycystic Kidney Disease
Sanem Guler, Sertac Cimen, Scott Hurton, Michele Molinari.....Pages 75-94

Chapter 5: Blood Pressure Control for Polycystic Kidney Disease
Rudolf P. Wüthrich, Andreas D. Kistler, Daniel Rodriguez,Sarika Kapoor, Changlin Mei.....Pages 95-108

Chapter 6: Clinical Trials in Autosomal Dominant Polycystic Kidney Disease
Alan S.L. Yu, Mireille El-Ters, Franz T. Winklhofer.....Pages 109-135

Chapter 7: Polycystins and Molecular Basis of Autosomal Dominant Polycystic Kidney Disease
Frederico Moraes Ferreira, Elieser Hitoshi Watanabe, Luiz Fernando Onuchic.....Pages 139-167

Chapter 8: The Role of Calcium and Cyclic AMP in PKD
James P. Calvet.....Pages 169-196

Chapter 9: Apoptosis in Polycystic Kidney Disease: From Pathogenesis to Treatment
Julie Xia Zhou, Xiaogang Li.....Pages 197-230

Chapter 10: c-Myc Signalling in the Genetic Mechanism of Polycystic Kidney Disease
Marie Trudel.....Pages 231-257

Chapter 11: The Role of G-protein Coupled Receptor Proteolytic Site (GPS) Cleavage in Polycystin-1 Biogenesis, Trafficking and Function
Feng Qian.....Pages 259-281

Chapter 12: Epigenetics in ADPKD: Understanding Mechanisms and Discovering Treatment
Xiaogang Li.....Pages 283-311

Chapter 13: MicroRNAs and Polycystic Kidney Disease
Sachin Hajarnis, Ronak Lakhia, Vishal Patel.....Pages 313-334

Chapter 14: Role of Inflammation in Polycystic Kidney Disease
Anil Karihaloo.....Pages 335-373

Chapter 15: Autosomal Dominant Polycystic Kidney Disease Induced by Ciliary Defects
Jong Hoon Park, Yu Mi Woo, Je Yeong Ko, Do Yeon Kim.....Pages 375-396

Chapter 16: Implications of Dysfunction of Mechanosensory Cilia in Polycystic Kidney Disease
Hannah C. Saternos, Wissam A. AbouAlaiwi.....Pages 397-421

Chapter 17: The Liver and Polycystic Kidney Disease
Mônica Souza de Miranda Henriques, Erick José de Morais Villar.....Pages 425-441

Chapter 18: Seminal Vesicles in Autosomal Dominant Polycystic Kidney Disease
Jin Ah Kim, Jon D. Blumenfeld, Martin R. Prince.....Pages 443-455

Chapter 19: Craniofacial Development and Growth in Polycystic Kidney Disease
Atsushi Ohazama, Paul T. Sharpe.....Pages 457-470

Chapter 20: Rapidly Progressive Glomerulonephritis in Autosomal Dominant Polycystic Kidney Disease
Adey A.A. Hasan, Raafat Makary, Leighton R. James.....Pages 471-483

Index
Pages 485-488

Book
The Whole Book

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  • Front Matter.....i-vii
  • Foreword.....Pages ix-x
  • Preface.....xi-xiii
  • Contributors.....xv-xx
  • Chapter 1: Differential Diagnosis of Autosomal Dominant Polycystic Kidney Disease.....Pages 3-19
  • Chapter 2: Childhood Polycystic Kidney Disease.....Pages 21-60
  • Chapter 3: Treatment and Management of Autosomal Dominant Polycystic Kidney Disease.....Pages 61-73
  • Chapter 4: Diagnosis and Treatment Modalities of Symptomatic Polycystic Kidney Disease.....Pages 75-94
  • Chapter 5: Blood Pressure Control for Polycystic Kidney Disease.....Pages 95-108
  • Chapter 6: Clinical Trials in Autosomal Dominant Polycystic Kidney Disease.....Pages 109-135
  • Chapter 7: Polycystins and Molecular Basis of Autosomal Dominant Polycystic Kidney Disease.....Pages 139-167
  • Chapter 8: The Role of Calcium and Cyclic AMP in PKD.....Pages 169-196
  • Chapter 9: Apoptosis in Polycystic Kidney Disease: From Pathogenesis to Treatment.....Pages 197-230
  • Chapter 10: c-Myc Signalling in the Genetic Mechanism of Polycystic Kidney Disease.....Pages 231-257
  • Chapter 11: The Role of G-protein Coupled Receptor Proteolytic Site (GPS) Cleavage in Polycystin-1 Biogenesis, Trafficking and Function.....Pages 259-281
  • Chapter 12: Epigenetics in ADPKD: Understanding Mechanisms and Discovering Treatment.....Pages 283-311
  • Chapter 13: MicroRNAs and Polycystic Kidney Disease.....Pages 313-334
  • Chapter 14: Role of Inflammation in Polycystic Kidney Disease.....Pages 335-373
  • Chapter 15: Autosomal Dominant Polycystic Kidney Disease Induced by Ciliary Defects.....Pages 375-396
  • Chapter 16: Implications of Dysfunction of Mechanosensory Cilia in Polycystic Kidney Disease.....Pages 397-421
  • Chapter 17: The Liver and Polycystic Kidney Disease.....Pages 425-442
  • Chapter 18: Seminal Vesicles in Autosomal Dominant Polycystic Kidney Disease.....Pages 443-455
  • Chapter 19: Craniofacial Development and Growth in Polycystic Kidney Disease.....Pages 457-470
  • Chapter 20: Rapidly Progressive Glomerulonephritis in Autosomal Dominant Polycystic Kidney Disease.....Pages 471-483
  • Index.....Pages 485-488
  • Book
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