Polycystic Kidney Disease

Authors

Xiaogang Li, PhD
Department of Internal Medicine, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA

Synopsis

Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD. Section 2 covers most of the fundamental molecular and cellular mechanisms underlying PKD, and how this knowledge is contributing to the development of potential novel therapeutic agents. Finally, section 3 focuses on extra-renal or secondary complications of PKD. Number of chapters 20; Contributors: 48; Figures: 42; Tables: 12; Pages: 488.

Electronic version is freely available. Hardcover copies are available at books@codonpublications.com

Chapters

  • Front Matter
    Pages i-vii
  • Foreword
    Jared J. Grantham.....Pages ix-x
  • Preface
    Xiaogang Li.....Pages xi-xiii
  • Contributors
    Pages xv-xx
  • Chapter 1: Differential Diagnosis of Autosomal Dominant Polycystic Kidney Disease
    Mariana Alves, Teresa Fonseca, Edgar A. F. de Almeida.....Pages 3-19
  • Chapter 2: Childhood Polycystic Kidney Disease
    Ameya Patil, William E. Sweeney Jr., Ellis D. Avner, Cynthia Pan.....Pages 21-60
  • Chapter 3: Treatment and Management of Autosomal Dominant Polycystic Kidney Disease
    Imed Helal.....Pages 61-73
  • Chapter 4: Diagnosis and Treatment Modalities of Symptomatic Polycystic Kidney Disease
    Sanem Guler, Sertac Cimen, Scott Hurton, Michele Molinari.....Pages 75-94
  • Chapter 5: Blood Pressure Control for Polycystic Kidney Disease
    Rudolf P. Wüthrich, Andreas D. Kistler, Daniel Rodriguez,Sarika Kapoor, Changlin Mei.....Pages 95-108
  • Chapter 6: Clinical Trials in Autosomal Dominant Polycystic Kidney Disease
    Alan S.L. Yu, Mireille El-Ters, Franz T. Winklhofer.....Pages 109-135
  • Chapter 7: Polycystins and Molecular Basis of Autosomal Dominant Polycystic Kidney Disease
    Frederico Moraes Ferreira, Elieser Hitoshi Watanabe, Luiz Fernando Onuchic.....Pages 139-167
  • Chapter 8: The Role of Calcium and Cyclic AMP in PKD
    James P. Calvet.....Pages 169-196
  • Chapter 9: Apoptosis in Polycystic Kidney Disease: From Pathogenesis to Treatment
    Julie Xia Zhou, Xiaogang Li.....Pages 197-230
  • Chapter 10: c-Myc Signalling in the Genetic Mechanism of Polycystic Kidney Disease
    Marie Trudel.....Pages 231-257
  • Chapter 11: The Role of G-protein Coupled Receptor Proteolytic Site (GPS) Cleavage in Polycystin-1 Biogenesis, Trafficking and Function
    Feng Qian.....Pages 259-281
  • Chapter 12: Epigenetics in ADPKD: Understanding Mechanisms and Discovering Treatment
    Xiaogang Li.....Pages 283-311
  • Chapter 13: MicroRNAs and Polycystic Kidney Disease
    Sachin Hajarnis, Ronak Lakhia, Vishal Patel.....Pages 313-334
  • Chapter 14: Role of Inflammation in Polycystic Kidney Disease
    Anil Karihaloo.....Pages 335-373
  • Chapter 15: Autosomal Dominant Polycystic Kidney Disease Induced by Ciliary Defects
    Jong Hoon Park, Yu Mi Woo, Je Yeong Ko, Do Yeon Kim.....Pages 375-396
  • Chapter 16: Implications of Dysfunction of Mechanosensory Cilia in Polycystic Kidney Disease
    Hannah C. Saternos, Wissam A. AbouAlaiwi.....Pages 397-421
  • Chapter 17: The Liver and Polycystic Kidney Disease
    Mônica Souza de Miranda Henriques, Erick José de Morais Villar.....Pages 425-441
  • Chapter 18: Seminal Vesicles in Autosomal Dominant Polycystic Kidney Disease
    Jin Ah Kim, Jon D. Blumenfeld, Martin R. Prince.....Pages 443-455
  • Chapter 19: Craniofacial Development and Growth in Polycystic Kidney Disease
    Atsushi Ohazama, Paul T. Sharpe.....Pages 457-470
  • Chapter 20: Rapidly Progressive Glomerulonephritis in Autosomal Dominant Polycystic Kidney Disease
    Adey A.A. Hasan, Raafat Makary, Leighton R. James.....Pages 471-483
  • Index
    Pages 485-488
  • Book
    The Whole Book

Biography

Xiaogang Li, PhD, Department of Internal Medicine, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA


Xiaogang Li, PhD, is the Director of the Epigenetics Core at the Kansas Polycystic Kidney Disease (PKD) Research and Translational Core Center, supported by the National Institutes of Health of the United States of America (USA). He is Associate Professor of Internal Medicine at the University of Kansas Medical Center (KUMC), USA. He also holds academic appointments at the Departments of Biochemistry and Molecular Biology, Anatomy and Cell Biology, and Cancer Biology at KUMC. His research encompasses both basic science and translational aspects of PKD. In particular, he is widely regarded as one of the world’s foremost authorities on epigenetics and renal inflammation in PKD. Furthermore, he re-evaluates the roles of apoptosis in autosomal dominant PKD, contributing to a better understanding of the mechanisms of this disease. He has published extensively in the field including publications in Nature Cell Biology, Nature Medicine, and Journal of Clinical Investigation. His studies are leading to the use of promising new therapeutic drugs in PKD treatment. 

Cover for Polycystic Kidney Disease

Details about the available publication format: Front Matter

Front Matter
ISBN-13 (15)
978-0-9944381-0-2
doi
10.15586/codon.pkd.2015.fm

Details about the available publication format: Foreword

Foreword
ISBN-13 (15)
978-0-9944381-0-2
doi
10.15586/codon.pkd.2015.fr

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Preface
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978-0-9944381-0-2
doi
10.15586/codon.pkd.2015.pr

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Contributors
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978-0-9944381-0-2
doi
10.15586/codon.pkd.2015.cont

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Chapter 1
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978-0-9944381-0-2
doi
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Chapter 2
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978-0-9944381-0-2
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Chapter 3
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978-0-9944381-0-2
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Chapter 4
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978-0-9944381-0-2
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Chapter 5
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978-0-9944381-0-2
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Chapter 6
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Chapter 7
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Chapter 8
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Chapter 9
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Chapter 10
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Chapter 11
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Chapter 12
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978-0-9944381-0-2
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Chapter 13
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978-0-9944381-0-2
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Chapter 14
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Chapter 15
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Chapter 16
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Chapter 17
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Chapter 18
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978-0-9944381-0-2
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Chapter 19
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Chapter 20
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Index
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Book
ISBN-13 (15)
978-0-9944381-0-2
doi
10.15586/codon.pkd.2015