Parkinson’s Disease: Pathogenesis and Clinical Aspects

Authors

Thomas B. Stoker, BA (Hons) MB BChir MRCP (UK) (ed)
John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK
Julia C. Greenland, MBBS MRes MRCP (UK) (ed)
John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK

Synopsis

Parkinson’s disease is an increasingly common neurodegenerative condition, which causes not only dysfunction of movement but also a broad range of nonmotor features, including mood disturbance, sleep dysfunction, autonomic dysfunction, cognitive deficits, and dementia, and neuropsychiatric symptoms. A major conundrum in this condition is understanding its striking clinical variability, which encompasses a spectrum from a benign phenotype with levodopa-responsive symptoms and minimal progression, to a malignant phenotype with rapid progression to severe gait dysfunction, falls and dementia. This book integrates the considerable expertise of a range of authors from different disciplines, from clinicians through to basic scientists, to present a comprehensive and up-to-date overview of Parkinson’s disease. In recent years, we have made significant progress in understanding the pathological and genetic basis of Parkinson’s disease and its heterogeneous forms, and the first section of the book is dedicated to reviewing this. The variable clinical features of Parkinson’s disease and its differential diagnosis are then considered. The final section provides a detailed overview of treatment approaches, including not only pharmacological therapies but also surgical therapies including deep brain stimulation and cell transplantation strategies. The combination of basic biology, clinical knowledge and therapeutics gives this book a very broad appeal. It will be of value to clinicians and health professionals caring for patients with Parkinson’s disease, as well as providing an excellent introduction for junior researchers entering the field.

Chapters

  • Front Matter
    Pages i-vi
  • Foreword
    Caroline Williams-Gray.....Page vii
  • Preface
    Thomas B. Stoker, Julia C. Greenland.....Page ix
  • Contributors
    Pages xi-xiii
  • Chapter 1: Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis
    Antonina Kouli, Kelli M. Torsney, Wei-Li Kuan.....Pages 3-26
  • Chapter 2: Immunogenetics of Parkinson’s Disease
    Itzia Jimenez-Ferrer, Maria Swanberg.....Pages 27-44
  • Chapter 3: Pathological Mechanisms and Clinical Aspects of GBA1 Mutation-Associated Parkinson’s Disease
    Thomas B. Stoker, Kelli M. Torsney, Roger A. Barker.....Pages 45-64
  • Chapter 4: Apoptosis and its Role in Parkinson’s Disease
    Nour S. Erekat.....Pages 65-82
  • Chapter 5: Animal Models of Parkinson’s Disease
    Elena A. Konnova, Maria Swanberg.....Pages 83-106
  • Chapter 6: The Differential Diagnosis of Parkinson’s Disease
    Julia C. Greenland, Roger A. Barker.....Pages 109-128
  • Chapter 7: Pharmacological Treatment of Parkinson’s Disease
    Insha Zahoor, Amrina Shafi, Ehtishamul Haq.....Pages 129-144
  • Chapter 8: Considerations for Patient and Target Selection in Deep Brain Stimulation Surgery for Parkinson’s Disease
    Robert F. Dallapiazza, Philippe De Vloo, Anton Fomenko, Darrin J. Lee, Clement Hamani, Renato P. Munhoz, Mojgan Hodaie, Andres M. Lozano, Alfonso Fasano, Suneil K. Kalia.....Pages 145-160
  • Chapter 9: Stem Cell Treatments for Parkinson’s Disease
    Thomas B. Stoker.....Pages 161-175
  • Index
    Pages 177-179

Author Biographies

Thomas B. Stoker, BA (Hons) MB BChir MRCP (UK), John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK

 

Tom_1501.jpg Dr. Tom Stoker is a neurologist, currently based at Addenbrooke’s Hospital, Cambridge, United Kingdom. After completing an intercalated degree in biological and biomedical sciences, he completed his medical degree at the University of Cambridge in 2012. Since then he has worked at a number of hospitals across the east of England, and he is currently working as a clinical research associate at the John van Geest Centre for Brain Repair at the University of Cambridge. His research involves the use of cell reprogramming techniques to study the mechanisms of, and test putative disease-modifying treatments for, Parkinson’s disease, with a particular interest in GBA1 mutation-associated Parkinson’s disease.

Julia C. Greenland, MBBS MRes MRCP (UK), John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, UK

 

Julia_1502.jpg Dr. Julia Greenland is a neurologist at Addenbrooke’s Hospital, Cambridge, United Kingdom. She graduated from Newcastle University in 2011 with a medical degree and an intercalated MRes degree, with a research focus on Parkinson’s disease. Following this, she has worked in a number of hospitals in the north-east and south of England, including the National Hospital for Neurology and Neurosurgery in London. She is currently working as a clinical research associate at the John van Geest Centre for Brain Repair, University of Cambridge. She is researching the involvement of the immune system in Parkinson’s disease, with a focus on targeting the peripheral immune system as a disease-modifying strategy.

Cover for Parkinson’s Disease: Pathogenesis and Clinical Aspects
Published
December 21, 2018

Details about the available publication format: Front Matter

Front Matter
ISBN-13 (15)
978-0-9944381-6-4