Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

Authors

Ian S. Zagon, PhD and Patricia J. McLaughlin, MS, DEd
Department of Neural & Behavioral Sciences, Pennsylvania State University College of Medicine Hershey, Pennsylvania

Synopsis

Multiple sclerosis is a chronic neurological disorder with devastating, long-term complications.  MS is incurable, and most therapies treat only the symptoms leaving the patient with a reduced quality of life for extended periods of time.  Most available therapeutic strategies target symptomatology, and not the pathophysiology of the disease.  This book focuses on different biological pathways associated with MS, and contains current information on the prevalence of multiple sclerosis, novel treatments that target pathophysiology, and new approaches for management of the disorder, as well as general knowledge about the disease process. Number of Chapters: 11, Contributors: 27; Figures; 14; Tables;7; Pages; 187. 

Electronic version is freely available. Hardcover copies are available at books@codonpublications.com

Chapters

  • Front Matter
    Pages.....i-vi
  • Foreword
    Anthony P. Turel.....Pages vii-viii
  • Preface
    Ian S. Zagon, Patricia J. McLaughlin.....Pages ix-xi
  • Contributors
    Pages.....xiii-xv
  • Chapter 1: The Genetics of Multiple Sclerosis
    Alessandro Didonna, Jorge R. Oksenberg.....Pages 3-16
  • Chapter 2: Living with Multiple Sclerosis in Europe: Pharmacological Treatments, Cost of Illness and Health Related Quality of Life Across Countries
    Lara Gitto.....Pages 17-37
  • Chapter 3: Multiple Sclerosis Therapies in Pediatric Patients: Challenges and Opportunities
    Jasna Jančić, Blažo Nikolić, Nikola Ivančević, Boris Henčić, Janko Samardžić.....Pages 39-52
  • Chapter 4: Neuropathic pain in multiple sclerosis – current therapeutic intervention and future treatment perspectives
    Kayla L. Murphy, John R. Bethea, Roman Fischer.....Pages 53-69
  • Chapter 5: Vitamin D and Multiple Sclerosis: An Update
    Insha Zahoor, Ehtishamul Haq.....Pages 71-84
  • Chapter 6: Stem Cell Therapy: A Promising Therapeutic Approach for Multiple Sclerosis
    Fereshteh Pourabdolhossein, Hatef Ghasemi Hamidabadi, Maryam Nazm Bojnordi, Sina Mojaver Rostam.....Pages 85-108
  • Chapter 7: Pathogenesis and progression of multiple sclerosis: the role of arachidonic acid-mediated neuroinflammation
    Sara Palumbo.....Pages 111-123
  • Chapter 8: Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis
    Ian S. Zagon, Patricia J. McLaughlin.....Pages125-138
  • Chapter 9: Immunomonitoring lymphocyte subpopulations in multiple sclerosis patients
    Aina Teniente-Serra, Cristina Ramo-Tello, Eva M Martinez-Caceres.....Pages 139-154
  • Chapter 10: Novel approaches of oxidative stress mechanisms in the multiple sclerosis pathophysiology and therapy
    Bożena Adamczyk, Natalia Niedziela, Monika Adamczyk-Sowa.....Pages 155-171
  • Chapter 11: Experimental in vivo models of multiple sclerosis: state of the art
    Sara Palumbo, Silvia Pellegrini.....Pages 173-183
  • Index
    Pages.....185-187

Author Biography

Ian S. Zagon, PhD and Patricia J. McLaughlin, MS, DEd, Department of Neural & Behavioral Sciences, Pennsylvania State University College of Medicine Hershey, Pennsylvania


Ian S. Zagon, PhD is Distinguished University Professor and Distinguished Educator at The Pennsylvania State University College of Medicine. He has had 4 decades of funded research resulting in more than 350 peer-reviewed publications, multiple patents and start-up companies. A significant discovery was identifying the mechanism of low dose naltrexone (LDN), and its role in diseases including diabetes, cancer, and multiple sclerosis. He has received numerous awards including the Cheston Berlin Service Award, Society of Experimental Biology and Medicine Distinguished Scientist Award, 27 consecutive annual Distinguished Teaching Awards, and the 2015 Innovator of the Year Award from Penn State University. 

Patricia J. McLaughlin, MS, DEd is tenured Professor at the Pennsylvania State University College of Medicine and Director of the Anatomy Graduate Program. She has collaborated with Dr. Zagon on basic and translational research, and has published extensively on the role of the OGF-OGFr axis in the etiology, pathogenesis, and treatment of a wide variety of diseases. Dr. McLaughlin has received the College of Medicine Dean’s Lecturer Award, as well as the SEBM Distinguished Scientist Award.  She has more than 15 patents on her work related to the OGF-OGFr axis, and is a co-founder, with Dr. Zagon, of ZoeGenics LLC. 

Cover for Multiple Sclerosis: Perspectives in Treatment and Pathogenesis
Published
November 8, 2017

Details about the available publication format: Front Matter

Front Matter
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017

Details about the available publication format: Foreword

Foreword
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.fr

Details about the available publication format: Preface

Preface
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.pr

Details about the available publication format: Contributors

Contributors
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.cont

Details about the available publication format: Chapter 1: The Genetics of Multiple Sclerosis

Chapter 1: The Genetics of Multiple Sclerosis
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch1

Details about the available publication format: Chapter 2: Living with Multiple Sclerosis in Europe: Pharmacological Treatments, Cost of Illness, and Health-Related Quality of Life Across Countries

Chapter 2: Living with Multiple Sclerosis in Europe: Pharmacological Treatments, Cost of Illness, and Health-Related Quality of Life Across Countries
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch2

Details about the available publication format: Chapter 3: Multiple Sclerosis Therapies in Pediatric Patients: Challenges and Opportunities

Chapter 3: Multiple Sclerosis Therapies in Pediatric Patients: Challenges and Opportunities
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch3

Details about the available publication format: Chapter 4: Neuropathic Pain in Multiple Sclerosis—Current Therapeutic Intervention and Future Treatment Perspectives

Chapter 4: Neuropathic Pain in Multiple Sclerosis—Current Therapeutic Intervention and Future Treatment Perspectives
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch4

Details about the available publication format: Chapter 5: Vitamin D and Multiple Sclerosis: An Update

Chapter 5: Vitamin D and Multiple Sclerosis: An Update
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch5

Details about the available publication format: Chapter 6: Stem Cell Therapy: A Promising Therapeutic Approach for Multiple Sclerosis

Chapter 6: Stem Cell Therapy: A Promising Therapeutic Approach for Multiple Sclerosis
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch6

Details about the available publication format: Chapter 7: Pathogenesis and Progression of Multiple Sclerosis: The Role of Arachidonic Acid–Mediated Neuroinflammation

Chapter 7: Pathogenesis and Progression of Multiple Sclerosis: The Role of Arachidonic Acid–Mediated Neuroinflammation
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch7

Details about the available publication format: Chapter 8: Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis

Chapter 8: Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch8

Details about the available publication format: Chapter 9: Immunomonitoring Lymphocyte Subpopulations in Multiple Sclerosis Patients

Chapter 9: Immunomonitoring Lymphocyte Subpopulations in Multiple Sclerosis Patients
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch9

Details about the available publication format: Chapter 10: Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Chapter 10: Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch10

Details about the available publication format: Chapter 11: Experimental In Vivo Models of Multiple Sclerosis: State of the Art

Chapter 11: Experimental In Vivo Models of Multiple Sclerosis: State of the Art
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ch11

Details about the available publication format: Index

Index
ISBN-13 (15)
978-0-9944381-3-3
doi
10.15586/codon.multiplesclerosis.2017.ind