Hepatocellular Carcinoma


Janina E.E. Tirnitz-Parker, MSc, PhD (ed)
School of Pharmacy and Biomedical Sciences, Curtin Heath Innovation Research Institute, Curtin University, WA, Australia


Hepatocellular carcinoma (HCC), the most common form of liver cancer, has become a major global health problem and is responsible for a steadily increasing number of cancer-related deaths. Although the risk factors for HCC development are well known and great advances have been made through HBV vaccinations, direct-acting antivirals for HCV treatment, and aflatoxin eradication programs, the overall incidence and mortality rates of HCC are still rising. To tackle the burden of HCC, it is essential to understand the principle molecular and cellular processes as well as fundamental clinical challenges. This book provides an overview on several important disease aspects. Chapter 1 reviews recent studies assessing the potential cellular origins of HCC. Chapter 2 describes the newly discovered regulatory roles of the tumor microenvironment on tumor growth and progression. Chapters 3 and 4 outline the most commonly used in vitro systems and animal models of chronic liver disease and HCC in detail. Chapter 5 provides an overview of metabolic reprogramming and dysregulation of lipid metabolism as a newly recognized hallmark of HCC. Chapter 6 details the currently accepted standards and challenges for the surgical management of HCC, while Chapter 7 provides an overview of the recent developments in the field of tyrosine kinase inhibitors. Chapter 8 discusses multidrug resistance to chemotherapy and potential approaches to overcome this clinical obstacle. The book, written by experts from several countries, addresses each topic in sophisticated detail. It will be a valuable resource for clinicians and investigators who are interested in HCC.


  • Front Matter
    Pages i-vi
  • Foreword
    Darrell Crawford, Geoffrey McCaughan…..Page vii
  • Preface
    Janina E.E. Tirnitz-Parker…..Page ix
  • Contributors
    Pages xi-xv
  • Chapter 1: Cellular Origin of Hepatocellular Carcinoma
    Doris Schneller, Peter Angel…..Pages 1-28
  • Chapter 2: The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
    Ina Sevic, Fiorella Mercedes Spinelli, María José Cantero, Andrea Reszegi, Ilona Kovalszky, Mariana Gabriela García, Laura Alaniz…..Pages 29-45
  • Chapter 3: In Vitro Models of the Liver: Disease Modeling, Drug Discovery and Clinical Applications
    Scott D. Collins, Gloria Yuen, Thomas Tu, Magdalena A. Budzinska, Kevin Spring, Katherine Bryant, Nicholas A. Shackel…..Pages 47-67
  • Chapter 4: Mouse Models of Hepatocellular Carcinoma
    Rodrigo Carlessi, Julia Köhn-Gaone, John K. Olynyk, Janina E. E. Tirnitz-Parker…..Pages 69-94
  • Chapter 5: The Role of Lipids in Hepatocellular Carcinoma
    C. Nelson Hayes, Peiyi Zhang, Kazuaki Chayama…..Pages 95-110
  • Chapter 6: Current Topics and Perspectives in Surgical Management of Hepatocellular Carcinoma
    Sebastian Lünse, Claus-Dieter Heidecke, Lars Ivo Partecke…..Pages 111-125
  • Chapter 7: Tyrosine Kinase Inhibitors in the Treatment of Hepatocellular Carcinoma
    Tiffany Sandra Wai Ling Khoo, Arif Rehman, John K. Olynyk…..Pages 127-139
  • Chapter 8: Multidrug Resistance in Hepatocellular Carcinoma
    Baojun Duan, Chen Huang, Jun Bai, Yu Lian Zhang, Xi Wang, Juan Yang, Jun Li…..Pages 141-158
  • Index
    Pages 159-165

Author Biography

Janina E.E. Tirnitz-Parker, MSc, PhD, School of Pharmacy and Biomedical Sciences, Curtin Heath Innovation Research Institute, Curtin University, WA, Australia


Editor_Photo_200.jpgJanina E.E. Tirnitz-Parker, MSc, PhD, is a tenured Associate Professor in the School of Pharmacy and Biomedical Sciences at Curtin University, Perth, Australia. She currently serves as Director on the Board of the Gastroenterological Society of Australia. She is the lead investigator of an international collaborative research team looking at the role of various signaling pathways during hepatocellular carcinoma and cholangiocarcinoma niche formation. Her research is funded by the National Health and Medical Research Council of Australia. Dr. Tirnitz-Parker has published many articles in the leading journals in the field, including Hepatology, Journal of Hepatology and Gastroenterology. She heads an independent and vibrant group of scientists and visiting researchers and supervises many PhD as well as Master’s degree students. In addition, she coordinates the Master’s unit on Stem Cell Biology and Regenerative Medicine at Curtin University. Dr. Tirnitz-Parker currently serves on the Editorial Board of several international scientific journals. As a passionate ambassador for liver and pancreatic cancer patients, she was selected to participate in the fourth cohort of Homeward Bound, an international leadership program for women in science, technology, engineering, maths, and medicine, culminating in an expedition to Antarctica in November 2019.

Cover for Hepatocellular Carcinoma
October 9, 2019